We are interested in understanding how plants defend themselves against pathogens. We study the HopZ family of type III effector proteins from Pseudomonas syringae and the immune responses they elicit in plant hosts. We use many different techniques to investigate plant immunity, including genetics, molecular biology, biochemistry, cell biology, genomics, high-throughput screens, and next-generation sequencing. Our long-term goals are to understand the molecular mechanisms of plant immunity, and to identify strategies for durable resistance in plants. We are a collaborative group of scientists who are committed to creativity, curiosity and excellence in science, training the next generation of scientists, and fostering a diverse inclusive welcoming environment that values all people.
The Lewis Lab is located at the Plant Gene Expression Center (PGEC) in Albany, California and is part of a unique collaboration between the Agricultural Research Service of the US Department of Agriculture and the Plant and Microbial Biology Department at the University of California, Berkeley.

Research Highlight

Our methods paper on a quantitative high-throughput yeast two-hybrid (QIS-Seq) is now out in Methods in Molecular Biology!

Research Highlight

Recognition of HopZ1a by ZED1 and ZAR1
Maёl, Jana and Karl's paper is now out in Plant Physiology!

Ilea joins the Lewis Lab!

Tomato seedling and P. syringae
Ilea, a first-year rotation student, has joined the Lewis Lab.

We welcome three new undergraduate students!

Schematic of bacteria
Undergraduate students Taylor, Zoe and RJ will be joining us for the summer, to investigate plant-pathogen interactions.

Research Highlight

Tomato seedling
Jana's tomato paper is now out in Molecular Plant-Microbe Interactions!

Congratulations to Lewis Lab Graduates in 2017!

Congratulations to Amy Zhu and Juan Alcauter, who graduated with their BSc degrees from UC Berkeley in May.

We welcome a new rotation student!

Tomato leaf
Ilea Chau is a new rotation student in the Lewis Lab.

Research Highlight

Cover art for SCDB special issue
Our review on the molecular mechanisms of effector recognition in plants is now out in Seminars in Cell and Developmental Biology.


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