ZAR1 Immune Receptor

HopZ1a is recognized in Col-0 wild type plants, causing a defense response while zar1 mutants lose the defense response
Pathogen effector proteins can be recognized by nucleotide-binding-site leucine-rich repeat receptors (NLRs), resulting in rapid defense responses. We developed ARTIC, the Arabidopsis Resistance gene T-DNA Insertion Collection, as a robust reverse genetic approach to identify NLRs that recognize specific effector proteins. We discovered that the Pseudomonas syringae type III effector protein HopZ1a is recognized by ZAR1. ZAR1 appears to be an ancient Resistance gene that is found in many plant species.