We are interested in understanding how plants defend themselves against pathogens. We study the HopZ family of type III effector proteins from Pseudomonas syringae and the immune responses they elicit in plant hosts. We use many different techniques to investigate plant immunity, including genetics, molecular biology, biochemistry, cell biology, genomics, high-throughput screens, and next-generation sequencing. Our long-term goals are to understand the molecular mechanisms of plant immunity, and to identify strategies for durable resistance in plants.
The Lewis Lab is located at the Plant Gene Expression Center (PGEC) in Albany, California and is part of a unique collaboration between the Agricultural Research Service of the US Department of Agriculture and the Plant and Microbial Biology Department at the University of California, Berkeley.

Research Highlight

Jana's paper has been accepted in Plant Direct!

Awards to current, former and visiting members of the lab!

Congratulations to Ilea, Taylor and Alice. Ilea received the Grace Kase fellowship. Taylor received a poster award at ABRCMS, and Alice received a grant to visit our lab.

Undergraduate course in Plant-Microbe Interactions

9 diseases that threaten your favorite foods
From coffee to bananas to grapes to potatoes, many plants are threatened by disease. Learn more about how plants defend themselves and how microbes cause disease. This upper-division undergraduate course (PMB165) is offered in the spring on Tuesdays and Thursdays from 9:30-11am.

We welcome a new rotation student!

Protein structure
Snigdha Chatterjee from Syracuse University, is a new rotating graduate student in the lab.

Research Highlight

Our methods paper on a quantitative high-throughput yeast two-hybrid (QIS-Seq) is now out in Methods in Molecular Biology!

Research Highlight

Recognition of HopZ1a by ZED1 and ZAR1
Maёl, Jana and Karl's paper is now out in Plant Physiology!

Ilea joins the Lewis Lab!

Tomato seedling and P. syringae
Ilea, a first-year rotation student, has joined the Lewis Lab.

We welcome three new undergraduate students!

Schematic of bacteria
Undergraduate students Taylor, Zoe and RJ will be joining us for the summer, to investigate plant-pathogen interactions.


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